Circadian Rhythm Regulator
Circadian Rhythm Regulator

Circadian Rhythm Regulator

Production process: Water extraction / Ethanol extraction
Active ingredient: Nobiletin
CAS No: 478-01-3
Specification: 98% HPLC
Grade: Food grade
Appearance: White powder with an off-white tone
Package specification: 25kg/drum
Mode of transportation: Express delivery, air freight, ocean freight
Delivery: Fast delivery from available inventory. Small-volume orders are dispatched via FedEx, while bulk shipments are arranged by air or sea.
OEM/ODM: Available
Minimum order quantity: 1kg, samples are available upon request
  • Free Samples
  • Quality Assurance
  • 24/7 Customer Service

Product Introduction

Circadian Rhythm Regulator – Premium Nobiletin Extract for Metabolic Wellness

Kang Biotech is an expert at making high-purity Circadian Rhythm Regulator ingredients from citrus fruits. We provide 98% pure Nobiletin extract (HPLC) to the global nutrition and functional food businesses. We have been making it for over 11 years and have a 33,000 m² factory. Over 20,000,000 m² of bitter orange farms are managed by our combined supply chain. This makes sure that the quality of each batch is the same and that the oranges are available all year. Our product ingredient meets high international safety standards for food-grade and supplement uses. It is certified under ISO 9001, ISO 22000, HACCP, Halal, Kosher, and FAMI-QS standards.

What Is Nobiletin as a Circadian Rhythm Regulator?

A polymethoxylated flavonoid called nobiletin is taken from orange peel, especially orange sinensis. It works as a natural product by supporting healthy metabolism and lifestyle choices.

Nobiletin is different from manufactured chemicals because it is very stable at high temperatures and easily dissolves in water. Your formulation teams can add it to functional drinks, food fortification projects, capsules, and tablets without changing how bioavailable it is.

Technical Specifications

Parameter Details
Botanical Source Citrus sinensis L.
Active Ingredient Nobiletin
CAS Number 478-01-3
Molecular Formula C28H34O15
EINECS Number 236-216-14
Specification Range 10%–98% HPLC
Standard Purity 98% HPLC
Grade Food Grade
Appearance White to off-white powder
Extraction Method Water extraction / Ethanol extraction
Package Size 25 kg/drum
MOQ 1 kg (samples available)
Shelf Life 24 months under proper storage

Core Advantages of Our Circadian Rhythm Regulator Ingredient

Natural Origin and Purity

Our Nobiletin extract only comes from citrus peel, which is extracted using advanced methods that use water or ethanol. You get an item with a clean name that doesn't have any artificial fillers or additives.

Vertical integration leads to a stable supply

From growing the plants to extracting the oil, we handle the whole process. This vertical integration gets rid of the need for third parties and makes sure that your orders are filled on time, even during busy times.

Stable and high bioavailability

The polymethoxylated structure of nobiletin makes it more stable when exposed to heat, light, and chemical stress. Your finished goods stay effective for a long time, which lowers the risk of having to reformulate them.

Documentation Ready for Compliance

Each batch has a full COA, MSDS, and papers showing that it meets all regulations. We help you get registered in North America, Europe, Japan, and South Korea by giving you detailed dossiers that have already been put together.

Quality Control of Circadian Rhythm Regulator

Quality assurance at Kang Biotech follows a multi-stage verification protocol. We conduct HPLC testing to confirm Nobiletin content at 98% purity. Microbial testing, heavy metal screening, and pesticide residue analysis are performed according to USP, EP, and JP standards.

Our laboratory maintains calibration traceability to international reference materials. You can request third-party testing reports from SGS or Eurofins for additional validation. Batch release only occurs after passing internal QC and external audits.

Application of Circadian Rhythm Regulator in Industry

Nutraceutical and Dietary Supplements

Nobiletin is used by formulators to make metabolic health capsules, sleep support mixes, and antioxidant blends. Because it works with both gelatin and veggie pills, it can be used by a wide range of people.

Foods and drinks that are good for you

Our Circadian Rhythm Regulator chemical is used by food companies to make energy bars, health drinks, and snacks with extra nutrients. The neutral taste of nobiletin and its high solubility make it easier to make new products.

Making research and development

Our high-purity Nobiletin is used in preliminary studies and formulation trials by pharmaceutical and biotech businesses. We give R&D projects small samples before they are scaled up to market levels.

Why Choose Kang Biotech as Your Supplier?

Direct Manufacturer with Support for R&D

The Hunan Institute of Agricultural Product Processing and Quality Safety and our company run a joint research center. Through this relationship, we can improve the efficiency of extraction and come up with custom specifications for your individual needs.

OEM and ODM services that are flexible

Our technical team works with you from the idea stage to the delivery phase of your project, whether you need private labeling, blended formulations, or custom purity levels. In different areas, we change how we package and record your products to meet your needs.

Logistics around the world and ready stock

We keep stock on hand so that we can ship right away. Small orders are sent out by FedEx within 48 hours, and bulk shipments are coordinated through either air or sea freight to get you the best landed costs.

More than 40 countries trust us.

There are people from Europe, North America, Japan, and South Korea who buy from us. We are committed to quality and service reliability, which is shown by our long-term partnerships with top nutraceutical brands.

OEM and ODM services

Packaging and Storage

Twenty-five kilograms are packed in a fiber box with two food-safe plastic bags inside. We also have sizes of 1 kg, 5 kg, and 10 kg for test runs or smaller production runs.

Keep away from direct sunlight and keep in a cool, dry place. Products that are kept in sealed containers stay fresh for up to 24 months. To keep things as fresh as possible, we suggest changing stock on a first-in, first-out schedule.

Packaging and Storage

FAQ

Q1: How does a product differ from standard sleep aids?

A: Unlike sedatives, a product shifts the actual timing of the biological clock rather than just inducing sleep. It supports natural rhythms without causing dependency.

Q2: What is the 'Melanopic EDI' requirement for office settings?

A: According to the WELL Building Standard, a minimum of 136 melanopic lux is recommended for daytime alertness. This applies primarily to lighting-based regulators.

Q3: Can a product be integrated with IoT?

A: Yes, modern regulators utilize API-driven controllers to sync with local sunrise/sunset data via GPS. This enhances precision in timing interventions.

Q4: Are there side effects to spectral regulation?

A: If improperly timed, regulators can cause 'phase delay,' making it harder to wake up. Professional SPD mapping is essential for safe implementation.

Q5: How is the ROI of a product measured?

A: Industry metrics focus on the reduction of 'Human Error Probability' (HEP) and improvements in the Stanford Sleepiness Scale (SSS) within industrial workforces.

Contact Us

Ready to source premium Nobiletin extract for your formulations with Circadian Rhythm Regulator? Contact our team at sales02@kangbiotech.com for technical datasheets, samples, and pricing.