Sugar Substitute Natural
Active ingredient: Neohesperidin Dihydrochalcone
CAS No: 20702-77-6
Specification: 98% HPLC tested
Grade: Food grade
Appearance: White powder
Package specification: 25 kg/drum
Mode of transportation: Express, air freight, sea freight
Delivery: Small orders by FedEx; large orders by air or sea.
Minimum order quantity: 1 kg, sample quantities supported.
- Free Samples
- Quality Assurance
- 24/7 Customer Service
Product Introduction
Sugar Substitute Natural – High-Purity NHDC Sweetener for Food & Beverage Applications
Kang Biotech provides pharmaceutical-grade Sugar Substitute Natural made from citrus bioflavonoids such Neohesperidin Dihydrochalcone (NHDC) with 98% purity validated by HPLC. Our 11-year manufacturing experience and control of 20,000,000 m² bitter orange orchards in Hunan Province assure consistent batch-to-batch output across 9 modern lines in our 33,000 m² facility.
Our NHDC has 1,500–1,800 times sucrose sweetness and few calories. It is useful for carbonated drinks, dairy formulas, and baked foods that require clean-label solutions since it is stable throughout pH 2–7 and can tolerate heat processing up to 200°C.

What Makes NHDC A Sugar Substitute Natural ?
Our product from citrus neohesperidin solves contemporary food science formulation problems. NHDC has a mellow sweetness profile with delayed onset and extended endurance, unlike artificial sweeteners that cause metallic aftertastes.
The chemical structure C28H36O15 enhances synergy with other sweeteners. This minimizes sugar use by 30–40% and masks protein beverage and herbal extract harshness. FEMA GRAS 3811, EU E959, and 40+ export market compliance are regulatory approvals.
Your formulation teams achieve aqueous solubility and high-temperature processing without caramelization. The white crystalline powder blends into dry mixtures, syrups, and emulsions without changing viscosity or cloudiness.
Technical Specifications
| Parameter | Specification |
|---|---|
| Botanical Source | Citrus Sinensis L. (Bitter Orange) |
| Active Compound | Neohesperidin Dihydrochalcone |
| CAS Number | 20702-77-6 |
| EINECS | 243-978-6 |
| Molecular Formula | C28H36O15 |
| Purity | 98% (HPLC Verified) |
| Appearance | White Crystalline Powder |
| Sweetness Potency | 1,500–1,800× Sucrose |
| pH Stability Range | 2.0–7.0 |
| Thermal Stability | Up to 200°C |
| Caloric Value | <0.2 kcal/g |
| Packaging | 25 kg/Fiber Drum |
Four Key Performance Advantages
1. Ultra-High Sweetness with Zero Glycemic Impact
The high sweetness of NHDC at 0.05–0.1% use levels greatly reduces formulation costs. The chemical is ideal for diabetic and keto-certified goods since it does not raise blood glucose or insulin response.
2. heat and acid stability
NHDC's pasteurization, UHT, and acidic pH resistance benefits your production operations. Retort sterilization and spray-drying preserve the sweetness of this Sugar Substitute Natural, unlike stevia, which destroys under heat.
3. Sweetener Synergy
NHDC with erythritol, allulose, or monk fruit extract generates a sucrose-like temporal profile. Independent sensory panels find 25% better sweetness and 40% fewer aftertastes than single-source alternatives.
4. Global Regulatory Compliance
Our ISO 22000, HACCP, Halal, Kosher, and FAMI-QS-certified NHDC streamlines regulatory filings. International launches are accelerated by GRAS status in North America and E-number certification in the EU.
Diverse Application Scenarios
Drink Mixtures
Carbonated soft drinks, sports nutrition, and ready-to-drink teas reduce sugar without affecting taste. In consumer studies, substitute 8–10% sucrose with 50–100 ppm NHDC and maintain sensory acceptability scores over 7.5/10.
Milk and Frozen Desserts
Protein smoothies, ice cream, and yogurt become sweet without crystallization. The powder dissolves uniformly in milk proteins and endures freeze-thaw cycles, delivering constant sweetness from manufacture to consumption.
Bakery/Confectionery
Cookie, cake, and hard candy use NHDC's Maillard reaction compatibility. In reduced-sugar formulations claiming 30% calorie reduction, add polyols for moisture retention and shelf life.
Dental and Drugs
NHDC's cooling and plaque-inhibiting characteristics aid toothpaste, mouthwash, and chewable tablets. At 20–30 ppm, the chemical hides acetaminophen and ibuprofen syrup harshness.
Quality Assurance and Certifications
Our 20 years of citrus extraction experience means strict quality standards. Batches undergo:
- HPLC purity verification with ±0.5% tolerance
- Heavy metal screening (Pb <0.5 ppm, As <0.2 ppm)
- USP-standard microbiological testing
- Analyzing residual solvent below ICH Q3C limits
The factory is ISO 9001:2015 and ISO 22000:2018 certified. Third-party audits verify sweetener application FDA 21 CFR 172.846 and EU Regulation 1333/2008 compliance.
Blockchain-verified supply chain records track citrus farms. This openness aids business sustainability reporting and non-GMO project verification.

Packaging and Logistics
Pharmaceutical-grade polyethylene bags in UN-certified fiber drums (25 kg net weight) are standard. Custom packaging includes:
- 1 kilogram lab foil pouches
- 10-kg intermediate bulk containers
- Private labeling with brand art
Based on order volume, we ship via several channels:
- Send 1–10 kg by FedEx in 5–7 days.
- Delivery to major airports takes 7–10 days by air freight (50–500 lb).
- Transporting >1,000 kg by sea in 25–35 days using consolidated containers
Commercial Invoice, Packing List, Certificate of Analysis, MSDS, and country-specific regulatory certifications accompany all shipments. First-time importers receive customs clearance assistance from our logistics staff.

FAQ
Q1: Does NHDC taste like stevia?
A: NHDC is sweeter and less licorice-like. Stevia requires substantial purification to eliminate off-flavors, yet our 98% pure NHDC tastes good in blind sensory testing.
Q2: What is the recommended beverage usage?
A: Use 60–80 ppm for non-carbonated beverages and 80–120 for carbonated systems. Background acidity and co-sweetener ratios determine adjustments. First-time users receive free formulation advice from our technical experts.
Q3: Can organic goods use NHDC?
A: Due to solvent extraction, our normal NHDC is natural but not organic. Water-extracted grades are available for USDA Organic and EU Organic projects.
Q4: How should the product be preserved for longevity?
A: Store in sealed containers below 25°C with <60% RH. Under these conditions, NHDC stays >98% pure for 36 months. Stay away from sunshine and powerful oxidizers.
Q5: Do you offer pilot-scale samples?
A: We ship 1 kilogram sample packets via FedEx in 5–7 days. Air freight carries 10–50 kilogram pilot amounts. Certificates of Analysis and application instructions included with each sample.
Contact Us
Ready to reformulate with Sugar Substitute Natural? Contact our technical sales team at sales02@kangbiotech.com for samples, pricing, and application support tailored to your project requirements.
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