Hesperetin Antioxidant Activity
Active ingredient: Hesperetin
CAS No: 520-33-2
Specification: 98% HPLC purity
Grade: Food grade
Appearance: Light yellow powder
Package specification: 25 kg fiber drum
Mode of transportation: Express, air cargo, sea cargo
Delivery: In-stock supply with worldwide shipping support.
OEM/ODM: Available for customized requirements
Minimum order quantity: 1 kg, samples available.
- Free Samples
- Quality Assurance
- 24/7 Customer Service
Product Introduction
Hesperetin Antioxidant Activity – Premium 98% HPLC Grade from Kang Biotech
Kang Biotech produces high-purity Hesperetin with confirmed Hesperetin Antioxidant Activity, utilizing advanced water and ethanol extraction techniques. Our flagship product is 98% HPLC pure and highly radical-scavenging for pharmaceutical, nutraceutical, and functional food applications.
With over 11 years of manufacturing expertise and 20,000,000 m² of regulated citrus orchards, we guaranty global supply throughout batches. The 33,000 m² facility has 9 contemporary manufacturing lines certified under ISO 9001, ISO 22000, HACCP, Halal, Kosher, and FAMI-QS standards. Thru a Joint Research Center with the Hunan Institute of Agricultural Product Processing, our ingredient solutions meet the highest antioxidant activity and bioavailability criteria.
What Is Hesperetin Antioxidant Activity?
The natural flavanone aglycone 3',5,7-trihydroxy-4'-methoxyflavanone has potent radical-scavenging and metal-chelating characteristics, which our product explains. Superoxide anions, hydroxyl radicals, and singlet oxygen are neutralized by HAT and SET.
Hesperetin's aglycone structure improves membrane permeability and Nrf2/HO-1 signaling than its glycoside cousin. This improves crude citrus extract bioavailability. Increased cellular absorption and faster antioxidant protection help formulations.
Shelf-unstable formulations prevent lipid peroxidation and systemic oxidative stress-induced inflammation. For companies wanting plant-based antioxidants with clear labeling, it is a viable option.
Technical Properties and Performance Indicators
Technical features make Hesperetin widely used in industry. The 302.28 g/mol molecular weight and C-5 and C-7 hydroxyl location promote electron delocalization and antioxidant potential.
Critical performance criteria for high-purity grades include high TEAC and low IC50 values in DPPH and ABTS tests, typically below 15 μg/mL. LogP of 2.4 balances lipophilicity for cellular absorption and aquatic delivery requirements.
The chemical may be employed in high-temperature food processing without degradation at 227-228°C. When used with Vitamin C or E, hesperetin boosts ORAC.
| Parameter | Specification |
|---|---|
| Active Ingredient | Hesperetin |
| CAS Number | 520-33-2 |
| EINECS Number | 236-216-9 |
| Molecular Formula | C16H14O6 |
| Purity Range | 80%-98% HPLC |
| Appearance | Light yellow powder |
| Melting Point | 227-228°C |
| LogP Value | ~2.4 |
| Grade | Food Grade |
| Package | 25 kg fiber drum |
Diverse Applications Across High-Demand Sectors
Cardiovascular supplements contain hesperetin, which prevents LDL cholesterol oxidation and improves endothelial function under high-oxidative stress. Your products' scientifically proven health advantages appeal to health-conscious consumers.
Advanced Cosmeceuticals: It neutralizes UVA-generated singlet oxygen in anti-aging serums. Formulators can use it instead of synthetic antioxidants to retain skin suppleness by inhibiting collagenase.
Functional Food Preservation: Hesperetin stabilizes omega-3-rich oils and other high-fat foods. It inhibits secondary oxidation products better than BHT and is clean-label. This meets customer desire for natural ingredients without affecting shelf life.
In complicated situations where pH changes and lipid-water interactions degrade weaker antioxidants, it performs well. Stability and sensory quality enhance shelf life for your items.
Rigorous Quality Control Standards
To standardize Hesperetin Antioxidant Activity, our quality inspection methodology considers numerous criteria. Our pharmaceutical-grade goods have 98% minimum HPLC purity for consistent radical scavenging kinetics.
DPPH Radical Scavenging Assay checks IC50 values against benchmarks in our testing methodologies. Total antioxidant power is measured by ORAC. GC-MS Residual Solvent Analysis eliminates ethanol and methanol from extraction.
ICP-MS heavy metal screening meets USP/EP requirements for Pb, As, Hg, and Cd. As micronization maximizes surface area for antioxidant interaction in solid dosage forms, PSD analysis is done. Our thorough processes ensure you obtain ingredients that meet international standards.

Why Choose Kang Biotech as Your Hesperetin Supplier?
We provide unsurpassed dependability as a direct manufacturer with an integrated supply chain from citrus farming to final manufacturing. Our 20,000,000+ m² plantation base guaranties consistent raw material quality and supply consistency.
We stock standard standards and accept orders from 1 kg samples to multi-ton commercial shipments. Ship worldwide by express, air freight, or sea cargo to satisfy your logistical needs.
Our OEM/ODM customisation services meet purity, particle size, packaging, and documentation needs. Your market positioning and regulatory demands are met with customized solutions.
Our goods fulfill strict global standards with ISO 9001, ISO 22000, HACCP, Halal, Kosher, and FAMI-QS certifications. To maximize formulation efficacy, our technical team provides extensive application support.

FAQ
Q: How does it compare to Hesperidin?
A: Hesperetin is aglycone. It's a stronger antioxidant and can enter cells better than hesperidin since it lacks the hefty sugar molecule.
Q: Does water maintain antioxidant activity?
A: Hesperetin doesn't mix well with water, but liposomal carriers or self-emulsifying delivery systems (SEDDS) prevent it from hardening.
Q: Do processing temperatures affect strength?
A: Hesperetin can resist 220°C with little loss of radical removal, making it suitable for scalding and extrusion.
Q: Can it work with other antioxidants?
A: It works nicely with Tocopherols and Ascorbic Acid. Hesperetin restores vitamins after free radical removal.
Q: How much need I ingest to observe an antioxidant impact in living things?
A: Taking 50 to 150 mg of high-purity Malondialdehyde (MDA) and other indicators of systemic oxidative stress decreased significantly in clinical testing.
Contact Us
Ready to enhance your formulations with Hesperetin Antioxidant Activity? Contact our team at sales02@kangbiotech.com for samples, technical documentation, and customized solutions tailored to your specific requirements.
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