Flavanone Aglycone

Flavanone Aglycone – High Bioavailability Plant Extract from Kang Biotech

In 2011, Kang Biotech began producing pharmaceutical-grade Flavanone Aglycone from premium oranges. Our 20,000,000 m² bitter orange plantation and 33,000 m² GMP-certified facilities guarantee consistent supply and batch-to-batch delivery. We manufacture Eriodictyol aglycone (CAS: 552-58-9) with 95%–98% purity (HPLC) for nutraceutical, functional food, and dermaceutical applications with over 11 years of experience. Sugar moieties are removed by our enzymatic hydrolysis process, increasing Cmax 3–5 times over glycosides. ISO 9001, ISO 22000, HACCP, Halal, Kosher, and FAMI-QS-certified, we provide dependable technical assistance and bespoke OEM/ODM solutions to 40+ countries.

What Is Flavanone Aglycone?

Our product contains sugar-free polyphenol flavonoids with a 2,3-dihydro-2-phenylchromen-4-one backbone. Eriodictyol, unlike glycosides Naringin and Hesperidin, is hydrolyzed by enzymes or acids.

These structural simplifications overcome bioavailability issues. Transforming gut microbiota is needed to absorb glycosides. The product allows for direct passive diffusion across intestinal epithelium, resulting in speedier onset, predictable plasma levels, and increased efficacy when used at lower dosages. Limiting crude citrus extract absorption is addressed.

Core Properties and Specifications

We offer higher physicochemical properties compared to glycosylated versions. Lack of bulky sugars enhances membrane permeability and lipophilicity.

The light yellow crystalline powder of Eriodictyol aglycone is thermally and oxidatively stable. For long-lasting compositions, it retains integrity after pasteurization and UHT processing.

Key Applications Across Industries

High bioavailability is important in three high-performance areas that our product serves.

The ingredient is used in quick-acting metabolic health supplements to control insulin sensitivity and lipid metabolism. There is no gastric lag time shown in clinical tests.

Eriodictyol aglycone is found in high-end liposomal serums. Small molecules can get into the stratum corneum and treat inflammation and make the skin brighter in ways that bigger glycosides can't.

Our product is an organic fortifier with a clean label that also works as a natural safeguard in drinks. It keeps working even in complex water-based mixtures and low-pH conditions where glycosides tend to form crystals or break down.

Quality Control and Testing Standards

For every Flavanone Aglycone batch, Kang Biotech uses pharmaceutical-grade quality assurance. We test more than international standards.

HPLC-DAD Analysis shows aglycone purity and glycoside removal completion. With GC-HS, no extraction solvents remain. To fulfill worldwide food safety standards, ICP-MS tests for Pb, As, Cd, Hg.

Dissolution rates are optimized via Laser Diffraction particle size distribution analysis. In water, micronized particles improve dispersion. USP <2021> criteria for Total Plate Count and Yeast/Mold limits are met in microbial testing.

Certificates of Analysis, allergy declarations, and stability data back all items. Innovative quality is guaranteed by our Joint Research Center with Hunan Institute of Agricultural Product Processing.

Why Choose Kang Biotech's Flavanone Aglycone?

We ensure traceability and quality consistency through our vertically integrated supply chain, from 20,000,000 m² citrus orchards to final manufacturing.

High bioavailability: Enzymatic hydrolysis eliminates sugar moieties, increasing plasma concentrations 3–5 times over glycosides. Lower doses of your formulas are therapeutic.

We provide customizable standards (95%–98% purity), particle size modification, and solubility enhancement by micronization or SEDDS integration.

ISO 22000, Halal, Kosher, and FAMI-QS certifications ensure your products fulfill European, North American, and Asia-Pacific regulations.

Trial orders (1 kg minimum) and large commercial shipments via FedEx, air, or sea freight are fulfilled by our 9 modern manufacturing lines and ample inventory.

Packaging and Logistics

Standard packaging: 25 kg/fiber drum with double food-grade PE bags inside. Custom packaging available for private label requirements.

Shipping methods: FedEx express (3–5 days), air freight (7–10 days), or sea freight for bulk orders. We provide complete documentation including COA, MSDS, and phytosanitary certificates.

FAQ

Q: Why replace citrus glycosides with the product?

A: Aglycones bypass gut microbiota cleavage, for 3–5 times higher peak plasma concentration and faster Tmax. Reliable bioavailability and effectiveness.

Q: How do you handle low water solubility?

A: SEDDS or micronization enhance surface area and dispersion in aqueous solutions.

Q: When sterilized at high heat, is it stable?

A: Aglycone structure does not degrade after pasteurization or UHT processing, unlike glycosides.

Q: What's the normal shelf life?

A: Accelerated stability testing shows it stays potent for 24–36 months in cold, dry, light-free circumstances.

Q: Does it meet clean-label standards?

A: Yes. Food-grade enzymes and solvents enable non-GMO and clean-label extraction.

Contact Us

Ready to elevate your formulations with Flavanone Aglycone? Contact our technical team at sales02@kangbiotech.com for samples, customization options, and application guidance.