GRAS Sweetener
Active ingredient: Neohesperidin Dihydrochalcone
CAS No: 20702-77-6
Specification: 98% HPLC assay
Grade: Food grade
Appearance: White powder
Package specification: 25 kg/drum
Mode of transportation: Courier service, air freight, ocean freight
Delivery: Fast shipping from available stock.
Minimum order quantity: 1 kg, sample supply supported.
- Free Samples
- Quality Assurance
- 24/7 Customer Service
Product Introduction
GRAS Sweetener – High-Purity Natural Sweetening Solution from Kang Biotech
Kang Biotech is a leading citrus extract-based GRAS Sweetener producer founded in 2011. Our flagship product, Neohesperidin Dihydrochalcone (NHDC), has 1,500–1,800 times sucrose sweetness at 98% HPLC purity. We operate a 33,000 m² GMP-compliant facility with 9 sophisticated production lines, with over 20,000,000 m² of managed bitter orange plantations and 11 years of manufacturing expertise. It's ISO 22000, HACCP, Kosher, Halal, and FAMI-QS certified. Sugar reduction solutions for food, beverage, and pharmaceutical sectors with reliable supply capacity and proven effectiveness in 40+ countries.
What Makes Our GRAS Sweetener Exceptional?
For clean-label industrial compositions, our product excels. Thermally stable throughout pH 2–7, the product can tolerate UHT and HTST processing without deterioration.
NHDC has a delayed onset and longer sweetness profile than sucrose. Artificial sweeteners' metallic aftertastes are eliminated by this feature.
Blended with other sweeteners, the substance works well. Improve taste complexity and economic efficiency while reducing sweetener use by 20–35%.
Technical Specifications
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Parameter
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Specification
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|---|---|
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Botanical Source
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Citrus Sinensis L.
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|
Active Ingredient
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Neohesperidin Dihydrochalcone (NHDC)
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|
CAS Number
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20702-77-6
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|
Molecular Formula
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C28H36O15
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|
Purity
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98% HPLC Assay
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|
EINECS Number
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243-978-6
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FEMA Number
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3811
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E Number
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E959
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Appearance
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White Powder
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|
Grade
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Food Grade
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Production Method
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Water / Ethanol Extraction
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Core Product Advantages
High Sweetness with Zero Calories
While adding zero calories, our GRAS Sweetener tastes 1,500–1,800 times sweeter than table sugar. It's ideal for low-calorie drinks, sugar-free sweets, and diabetic items.
Processing Stability
Thru rigorous heat procedures, NHDC maintains molecular integrity. You use the same formulas for carbonated drinks, retort-processed sauces, and high-temperature baked items.
Long-term shelf storage does not degrade the substance. Stability studies show performance retention beyond 24 months in suitable storage.
Improved Flavor Interaction
With other sweeteners, NHDC enhances sweetness perception beyond additive effects. You can improve sweetness delivery and reduce sweetener load by one-third with this combination.
It also conceals bitterness in protein drinks, botanical extracts, and APIs. The dual function simplifies formulation development.
Straightforward sweetness
NHDC has a smooth sweetness curve without bitterness or chemical aftertastes, unlike certain high-intensity sweeteners. The sensory profile resembles natural sugar, boosting clean-label consumer adoption.
Quality Assurance & Manufacturing
Kang Biotech has international-standard quality management systems. ISO 9001, ISO 22000, HACCP, and FAMI-QS are strictly followed at our facilities.
Every batch is rigorously tested:
Purity: HPLC shows 98% minimum active content.
Heavy metal screening: ICP-MS testing confirms Lead <0.5 ppm and Arsenic <0.5 ppm.
Analysis: Total Plate Count <1000 cfu/g, no pathogens.
Particle size distribution and moisture content verification
Residual Solvent Testing: GC-HS confirms solvent levels below ICH limits
Our Joint Research Center with the Hunan Institute of Agricultural Product Processing advances extraction efficiency and product quality.

Versatile Application Solutions
Drink Mixtures
Use the product in functional waters, zero-sugar carbonated drinks, and ready-to-drink teas. The substance retains sweetness for 12 months in acidic settings (pH 2.5–4.0).
Bakery/Confectionery
Make sugar-free cookies, protein bars, and gum with NHDC. Without Maillard browning, the sweetener stays chemically stable at baking temperatures above 180°C.
Nutrition Specialty
Add to pediatric syrups, sports nutrition powders, and meal replacement shakes. Its non-cariogenic qualities cover bitter active ingredients and support tooth health claims.
Pharma Applications
Use NHDC to conceal flavor in sugar-free oral solutions and chewable tablets. Batch-to-batch uniformity enables pharmaceutical regulatory compliance.
Packaging & Logistics
Standard packaging: 25 kg/fiber drum, double polyethylene inner bags.
Minimum order: 1 kilogram for assessment samples
Shipping Options:
FedEx/DHL for samples and small orders
Medium-volume air freight
Ocean freight for business bulk orders
Orders typically ship within 3–5 business days from ready stock.

FAQ
Q: What separates FDA-notified from self-affirmed GRAS?
A: GRAS is FDA-notified after a "no questions" safety examination. Self-affirmed status means an independent expert panel determined safety without FDA approval. Both methods enable lawful marketing, but notification boosts buyer confidence.
Q: Does NHDC survive flash pasteurization?
A: Yes. HTST (High-Temperature Short-Time) processing keeps our sweetener functioning for most commercial beverage manufacturing lines.
Q: Is this substance natural?
A: Controlled hydrogenation converts bitter orange neohesperidin into NHDC. Many clients effectively place it in natural product formulations, but labeling should follow regional restrictions.
Q: What synergistic effects occur when blending sweeteners?
A: NHDC enhances sweetness when mixed with other sweeteners. You'll receive 15–30% synergistic increase, reducing sweetener use while retaining sweetness.
Q: What is the standard shelf life?
A: Our product meets specifications for 24–36 months when stored in sealed packaging in cool, dry circumstances.
Contact Us
Ready to optimize your formulation with our high-purity GRAS Sweetener? Contact our technical team at sales02@kangbiotech.com for samples, specification sheets, or application support.
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