Pharmaceutical Sweetener

Pharmaceutical Sweetener – High-Purity NHDC for Enhanced Oral Formulations

Kang Biotech offers Neohesperidin Dihydrochalcone (NHDC) Pharmaceutical Sweetener solutions with 98% HPLC purity. With 11 years of citrus extraction experience and 20,000,000 m² of controlled bitter orange farms, we offer sweeteners 1,500-1,800 times sweeter than sucrose, with  thermal stability at pH 2-7. The ISO 9001, ISO 22000, HACCP, Halal, Kosher, and FAMI-QS certifications of our NHDC provide batch-to-batch consistency for pharmaceutical, nutraceutical, and functional food applications. Our sweetener, ex-stock in 25 kilogram drums, speeds oral suspension, effervescent tablet, and taste-masked dosage form preparation.

Why NHDC Excels as a Pharmaceutical Sweetener

Neohesperidin Dihydrochalcone's dual action makes it unique among pharmaceutical excipients. It hides harsh APIs in pediatric and geriatric syrups and provides strong sweetness with low caloric input.

NHDC's non-cariogenic qualities make it appropriate for long-term chewable pills and lozenges. We assist diabetic medication compliance with our NHDC, which has no glycemic influence.

The compound's synergistic compatibility with other sweeteners reduces excipient loading. This optimization decreases your cost of goods and improves problematic formulations' sensory character.

Technical Specifications

Proven Applications in Pharmaceutical Formulations

Our Pharmaceutical Sweetener works well in various dosages. In liquid oral solutions, NHDC neutralizes macrolide antibiotic metallic notes without affecting API stability over shelf life.

NHDC in granulation gives orally disintegrating tablets rapid palatability. ODT formulations release flavors quickly while preserving tablet hardness for commercial packaging.

NHDC's chemical inertness helps effervescent systems evolve CO2. Even in high-sodium bicarbonate conditions with frequent pH fluctuations, the sweetener maintains patient acceptability across chronic therapy cycles.

Quality Assurance and Compliance

Each batch is tested according to ICH Q3D and USP-NF requirements. HPLC assay verification, GC-MS residual solvent analysis, and heavy metal screening below pharmacopeial limits are part of our quality protocol.

Microbiological testing includes TAMC and TYMC. Laser diffraction controls particle size distribution for homogeneous direct compression mixing.

All analytical paperwork for FDA, EMA, and PMDA regulatory filings is provided. Our food-grade, medicinal, and nutraceutical certifications simplify multi-market compliance.

Manufacturing Advantages That Support Your Supply Chain

At our 33,000 m² production facility, nine modern extraction lines are supported by a Joint Research Center with the Hunan Institute of Agricultural Product Processing. This infrastructure ensures year-round supply despite seasonal raw material changes.

Vertical integration from farming to packing removes intermediate concerns. Your procurement team gets predictable lead times, batch traceability, and variable order amounts from 1 kg samples to multi-ton commercial shipments.

We provide FedEx express, air freight, and sea freight to meet project deadlines. Stock allows urgent formulation experiments and bridge investigations without sacrificing quality verification.

Custom Formulation Support

Our OEM/ODM services solve formulation problems beyond conventional requirements. Our technical staff participates throughout development to customize particle size for inhalation goods and moisture content for effervescent mixes.

We help with sweetener synergy studies to balance excipients for specific sensory profiles at low cost. Application consulting includes stability and innovative API compatibility testing.

FAQ

Q: What is the Acceptable Daily Intake (ADI) for NHDC in pediatric formulations?

A: JECFA has found NHDC acceptable for pediatric use with an ADI of 0–5 mg/kg body weight.

Q: Does NHDC alter oral suspension API bioavailability?

A: NHDC does not affect API absorption kinetics since it is pharmacologically inert and does not change stomach pH or intestinal permeability.

Q: How does NHDC perform in hot-melt extrusion processes?

A: Our product is stable up to 180°C for melt granulation and hot-melt coating without deterioration or color change.

Q: Can diabetics consume sugar-free NHDC?

A: NHDC is utilized in diabetes-friendly oral treatments and supplements since it has no glycemic load.

Q: What particle size is best for direct compression tablets?

A: For optimal flow and homogeneity in high-speed tablet presses, we provide NHDC with D50 values of 50-150 μm.

Contact Us

Secure your supply of high-purity Pharmaceutical Sweetener backed by 11+ years of manufacturing. Contact our team at sales02@kangbiotech.com to request samples, technical data sheets, or custom formulation support today.