Hesperetin Dihydrochalcone Glucoside
Active ingredient: Neohesperidin Dihydrochalcone (NHDC)
CAS No: 20702-77-6
Specification: 98% HPLC
Grade: Food grade
Appearance: Fine white powder
Package specification: 25 kg fiber drum
Mode of transportation: Express delivery, air freight, sea freight
Delivery: Ready stock with fast shipment. FedEx for small orders, air or sea for bulk cargo.
Minimum order quantity: 1 kg, sample orders accepted.
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Product Introduction
Hesperetin Dihydrochalcone Glucoside: Premium Citrus-Derived Functional Ingredient
Kang Biotech produces water-soluble citrus flavonoid derivative Hesperetin Dihydrochalcone Glucoside with purity above 98% HPLC using sophisticated glycosylation. We have 11 years of manufacturing expertise and 20,000,000 m² of bitter orange plantations. Our 33,000 m² production facility has 9 specialized extraction lines for reliable batch-to-batch outcomes.
This glucosylated dihydrochalcone possesses 1000-fold greater water solubility than native hesperetin, thermal stability up to 140°C, and chemical stability pH 3.0–7.5. Our substance meets REACH, FEMA 3811, E959, and FCC regulations.
Product Specifications
| Parameter | Detail |
|---|---|
| Botanical Source | Citrus Sinensis L. / Citrus Aurantium |
| Active Compound | Hesperetin Dihydrochalcone Glucoside |
| CAS Number | 20702-77-6 |
| EINECS | 243-978-6 |
| FEMA | 3811 |
| CEE Number | E959 |
| Molecular Formula | C28H36O15 |
| Specification | 98% HPLC |
| Appearance | Fine white to light yellow powder |
| Water Solubility | >50g/L |
| pH Stability Range | 3.0–7.5 |
| Thermal Stability | Up to 140°C |
| Grade | Food/Nutraceutical/Cosmetic |
| Package | 25 kg fiber drum |
| MOQ | 1 kg (samples accepted) |
What Makes This Hesperetin Dihydrochalcone Glucoside Different
Traditional citrus flavonoids have been bio-optimized into the product. This chemical overcomes three everyday formulation issues for your R&D teams by precisely glucosylating the dihydrochalcone structure.
It first reduces natural flavonoids' notoriously low water solubility. Second, it slows non-glycosylated substances' metabolic breakdown. Third, it eliminates high-intensity sweetener systems' unpleasant aftertaste.
A perfect lipophilicity-hydrophilicity equilibrium is achieved by glucose. Better absorption in nutraceuticals and deeper epidermal penetration in topicals. You obtain consistent performance across distribution types.
Core Technical Advantages
High Solubility
Our Hesperetin Dihydrochalcone Glucoside dissolves quickly in water without co-solvents or emulsifiers. This simplifies formulation and lowers ingredient prices. Crystalline suspension prevents precipitation during storage.
Outstanding Processing Stability
Pasteurization, spray drying, and high-temperature short-time processing give your production teams confidence in this component. The deterioration rate is less than 1% after 6 months in pH 3.2 carbonated drinks at room temperature. This stability enhances product shelf life and decreases reformulation.
Clear Regulations
The substance is GRAS and meets FEMA flavor ingredient lists in key markets. Our manufacture is ISO 9001, ISO 22000, HACCP, Halal, Kosher, and FAMI-QS certified. Full regulatory submission material is provided.
Industry Applications
Functional Beverage Optimization
This potent bitter blocker found in sugar-reduced drinks. It reduces the metallic taste of potassium acesulfame and steviol glycosides and improves mouthfeel. Your taste buds will appreciate lower sweetener doses.
Advanced Skincare Ingredients
Stable tyrosinase inhibitor for skin-brightening products at 0.5%–2.0%. In oxidative stress, resistant glucoside bonds outperform vitamin C derivatives. Formulators like its cationic surfactant and carbomer gel compatibility.
Nutritional Delivery Systems
Its liquid-filled capsules and oral sprays include highly accessible dihydrochalcone antioxidants. Your clients get stable blood plasma levels without precipitation from flavonoid supplements. The substance operates in water- and oil-based matrices.
Quality Assurance Framework
Laboratory Testing
Reverse-Phase HPLC tests every batch to ensure the alpha/beta-glucoside ratio matches efficacy standards. To fulfill international food and drug safety regulations, we use ICP-MS to test residual catalysts and heavy metals (Pb, As, Hg, Cd).
Microbiological Control
TAMC and TYMC tests are part of our quality control. Product Certificates of Analysis list all quality characteristics.
Stability Testing
For hydrolysis monitoring, we use ICH Q1A stability stress testing. Our data shows shelf-life over 24 months under conventional storage circumstances (below 25°C, dry, UV-protected).

Production and Supply Capabilities
From cultivation to production, Kang Biotech has an integrated supply chain. Our 9 modern production lines keep goods ready for transportation. Our FedEx logistics for small shipments and air/sea freight for big amounts are versatile.
Our technical staff provides formulation advice, stability testing data, and application advice. For seamless ingredient integration, we collaborate with your R&D and quality teams.

Packaging and Logistics
Packaging employs 25 kilogram fiber drums with moisture-resistant inner liners. Our OEM/ODM packaging is customized. With formulation trial samples, minimum order is 1 kilogram.

FAQ
Q: What distinguishes the product from Neohesperidin DC?
A: Both dihydrochalcones, however the glucoside form is more water-soluble and sweetens faster without the licorice-like aftertaste of neohesperidin derivatives.
Q: Are low-pH carbonated beverages stable?
A: Acidic beverages can use it since it degrades less than 1% over 6 months in pH 3.2 at room temperature.
Q: The food usage regulation status?
A: It fulfills GRAS and FEMA flavor ingredient lists in most jurisdictions, enabling global market access.
Q: What about other skincare actives?
A: No, its non-ionic nature is compatible with cationic surfactants and carbomers, simplifying formulation.
Q: What storage conditions avoid clumping?
A: Under hermetically sealed containers under cold (below 25°C), dry, UV-protected conditions, avoid photo-oxidation and keep free-flowing powder.
Contact Us
Ready to solve your formulation challenges with Hesperetin Dihydrochalcone Glucoside? Contact our technical sales team at sales02@kangbiotech.com for detailed specifications, sample requests, and application support tailored to your project requirements.
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