Neohesperidin 98%
Active ingredient: Neohesperidin
CAS No: 13241-33-3
Specification: 98% HPLC tested
Grade: Food grade
Appearance: White powder to off-white powder
Package specification: 25 kg/drum
Mode of transportation: Express delivery, air shipment, sea shipment
Delivery: Fast shipment from stock. Small orders are sent via FedEx, while large orders are shipped by air or sea.
OEM/ODM: Available
Minimum order quantity: 1 kg, samples available.
- Free Samples
- Quality Assurance
- 24/7 Customer Service
Product Introduction
Neohesperidin 98% – Premium Citrus Flavonoid for Pharmaceutical & Nutraceutical Applications
Neohesperidin 98%, made from carefully selected Citrus aurantium L. (bitter orange) peels, is our core product. Pharmacy-grade Neohesperidin with reliable batch quality. Our extraction of citrus fruits spans 11 years, with 20,000,000 m² of maintained bitter orange plantations in Lianyuan, Hunan Province. The item is 98% pure, according to HPLC. It is essential to manufacturing NHDC and can be utilized in drugs, vitamins, and animal feeds. With ISO 9001, ISO 22000, HACCP, Halal, Kosher, and FAMI-QS certifications, our integrated supply chain delivers orders securely to over 40 countries.
What Is Neohesperidin 98%?
In immature, bitter orange peels, our product is a crystal-clear flavanone glycoside. Its neohesperidose sugar structure converts it into high-intensity natural sweetener Neohesperidin Dihydrochalcone (NHDC).
Three major commercial issues are solved by this luxury element. It eliminates off-notes and bitterness in pharmaceutical and functional food compositions. Additionally, it contains natural antioxidant activity that doesn't decrease when cooked. Third, ultra-pure steps between NHDC batches produce consistency.
Good stability and extensive application in food, pharmaceutical, and animal feed improve your products.
Technical Specifications & Properties
Understanding the technical characteristics helps you integrate this ingredient confidently into your formulations.
| Parameter | Specification |
|---|---|
| Botanical Source | Citrus aurantium L. (Bitter Orange) |
| Active Ingredient | Neohesperidin |
| CAS Number | 13241-33-3 |
| EINECS Number | 236-216-9 |
| Molecular Formula | C28H34O15 |
| Molecular Weight | 610.56 g/mol |
| Purity | 98% (HPLC tested) |
| Appearance | White to off-white crystalline powder |
| Melting Point | 236-237°C |
| Solubility | Sparingly soluble in cold water; soluble in hot water, ethanol, alkaline solutions |
| Specific Rotation | [α]D20 -80° to -90° (in methanol) |
| pH Stability | 2.0-7.0 (ideal for acidic formulations) |
| Loss on Drying | ≤5.0% |
| Grade | Food & Pharmaceutical Grade |
The 98% purity ensures minimal impurities (Hesperidin and Naringin <1.0%), providing optimal performance in sensitive applications like pediatric formulations and high-end nutraceuticals.
Key Applications in High-Performance Formulations
Neohesperidin 98% works very well in three specific situations where purity and usefulness are very important.
Pharmaceuticals Covering Up Bitterness
This ingredient can be added to oral liquids and chewable pills for kids. It does a good job of hiding the strong bitterness of active ingredients like Ibuprofen or Macrolides without affecting their therapeutic effectiveness. Your pediatric formulations taste better, which makes patients more likely to take them as prescribed.
Putting together Neohesperidin DC (NHDC)
The 98% pure grade is required because it is the main substance in the hydrogenation process. It stops unwanted taste by-products from getting into the end sweetener, which makes sure that your NHDC has the same organoleptic profiles from batch to batch.
Animal nutrition that works
It makes the food taste better and protects against free radicals in high-end veterinarian formulas. Getting rid of the metallic taste of vitamin and mineral premixes can help young pigs eat more of their food. At the same time, it supports the health of the gut mucosa, which is useful in more ways than one.
Comprehensive Quality Control Framework
Our product quality assurance is based on four important pillars that protect the reputation of your brand.
Analysis of Purity
We employ HPLC-DAD—"High-Performance Liquid Chromatography with Diode Array Detection."—to check 98%. This approach additionally evaluates relevant citrus flavonoids to ensure your compositions have the right phytochemical profile.
Heavy Metal Cleanup
USP <232> regulations are strictly followed in our manufacture. Mercury, arsenic, and lead remain below 0.1, 0.5, and 0.5ppm. Your goods fulfill worldwide safety requirements without modification.
Monitoring solvent residue
GC-MS testing ensure that ethanol or methanol levels are considerably below ICH Q3C restrictions. This protects your formulas from consumer safety concerns and regulation violations.
Microbiology Integrity
The plate count (<1000 cfu/g), yeast and mold count (<100 cfu/g), and absence of E. coli and Salmonella are carefully examined. Your substances are sterilized and ready for pharmaceutical and nutraceutical usage.

Why Choose Kang Biotech as Your Neohesperidin 98% Supplier?
Vertical integration makes a company a direct manufacturer.
Our 20,000,000+ m² of bitter orange farms and 33,000 m² production center make the whole supply chain clear to you. You benefit from stable prices and quality that stays the same no matter how much you order.
Advanced Tools for Making Things
Nine high-tech production lines with the latest extraction technology make sure that each batch is the same. Our technical team, which has over 20 years of experience extracting citrus fruits, follows strict quality standards all the way thru the production process.
Customization services that are flexible
We offer OEM and ODM services that are made to fit your needs. Our R&D team works with you to meet the specific needs of your market, whether you need custom purity levels, packaging, or help with manufacturing.
Compliance and Certifications Around the World
ISO 9001, ISO 22000, HACCP, Halal, Kosher, and FAMI-QS standards are all met by our manufacturing systems. This method of getting multiple certifications makes sure that your goods meet the rules for many places and uses.
Supply you can count on and quick delivery
For regular requirements, we keep stock on hand. FedEx ships small trial orders, while air or sea freight is used for commercial volumes, depending on your time frame needs. The smallest amount you can order is just 1 kg, and you can get samples to try before you buy.

Packaging & Storage Recommendations
Standard packaging comes in 25 kg/drum sizes that are meant to keep the quality of the product while it is being shipped and stored.
Neohesperidin should be kept in a cool, dry place that is out of direct sunlight and away from water. The product keeps its 98% assay for 24 months if it is kept in sealed cases and kept in the right circumstances. This longer shelf life cuts down on inventory loss and gives you more options for planning your production.

FAQ
Q: How does the product vary structurally from Hesperidin?
A: Both are citrus flavanones, however Neohesperidin has 1-2 linkage neohesperidose sugar. Hesperidin has 1-6-linked rutinose sugar. Hesperidin cannot convert into the very sweet NHDC, but Neohesperidin may due to its structural difference.
Q: Does the product taste sweet?
A: Not like its derivative NHDC, this substance tastes harsh and citrus-like. Only hydrogenation to NHDC creates sweetness.
Q: How should product be kept to retain 98% assay?
A: Store away from direct light and moisture in a cool, dry location. It is stable for 24 months in closed containers. The right storage reduces deterioration and microbiological infection.
Q: Does your product have food safety certification?
A: Yes. Our premium batches are ISO, Kosher, and Halal-certified. This satisfies worldwide food, pharmaceutical, and nutraceutical regulations.
Q: What is the 98% grade moisture limit?
A: LOD is carefully limited at ≤5.0%. Limiting microbial growth ensures product stability during shelf life.
Contact Us
Ready to enhance your formulations with pharmaceutical-grade Neohesperidin 98%? Contact our technical team at sales02@kangbiotech.com for product samples, pricing information, and application support tailored to your specific requirements.
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