Nobiletin 478-01-3

Nobiletin 478-01-3 – Premium Polymethoxylated Flavone from Kang Biotech

Kang Biotech makes high-purity Nobiletin 478-01-3, a polymethoxylated flavonoid from Citrus sinensis L. peel. Over 11 years of production experience and 20 years of citrus extraction technology enable us to offer 98% pure pharmaceutical and food-grade Nobiletin (HPLC). Our 33,000 m² manufacturing facility and 20,000,000+ m² citrus farms guarantee consistent supply and batch-to-batch quality. ISO 9001, ISO 22000, HACCP, Halal, Kosher, and FAMI-QS-certified, we provide dependable quality and adaptable OEM/ODM solutions to 40+ countries.

What is Nobiletin 478-01-3?

O-methylated polymethoxylated flavone product is typical. It comes largely from Mandarin orange and Citrus sinensis peels.

This lipophilic bioactive compound is found in nutraceuticals and medicines. Unlike other flavonoids, its six methoxy groups boost cellular membrane permeability and cause it to cross the blood-brain barrier.

This is crucial for neuroprotective, circadian rhythm stabilizer, and metabolic health supplement makers. Industrial concerns include standardizing, high-potency citrus extracts and bioavailability.

Technical Specifications and Properties

This chemical, C21H22O8, weighs 402.39 g/mol and is known as 5,6,7,8,3',4'-hexamethoxyflavone. For premium grades, HPLC tests must indicate purity ≥98%.

A thin crystalline powder, it's off-white to pale yellow. The chemical is suited for gastric transit in oral administration systems due to its melting point of 137-138°C and acidic stability.

Professional Quality Control Standards

Kang Biotech conducts thorough quality control for Nobiletin 478-01-3 across five essential pillars to assure B2B procurement safety.

Purity Verification: HPLC-DAD analysis eliminates PMFs like Tangeretin that can alter bioactivity profiles.

Heavy Metal Screening: ICP-MS testing for Pb, As, Cd, and Hg fulfills strict international food safety standards. We adhere to USP <232> regulations, assuring Lead <0.5 ppm and Arsenic <1.5 ppm.

Gas Chromatography (GC) assures methanol or ethanol residues are below 5000ppm or 50ppm, depending on grade.

Microbiological Profiling: TPC, Yeast, and Mold tests confirm nutraceutical sterility. For consistent solid dosage form mixing and dissolving, Particle Size Distribution employs laser diffraction analysis (D50/D90).

Key Applications in Professional Formulations

Our product is used in three professional settings worldwide.

Cognitive Health and Neuroprotection: Regulates clock gene expression as a ROR agonist in B2B nootropics. This helps treat Alzheimer's and cognitive impairment in difficult clinical settings.

To manage metabolic syndrome, dietary supplements can target SIRT1 and PGC-1α pathways, improving lipid metabolism and glucose homeostasis in obese or Type 2 diabetic patients.

High-end topical anti-aging products block Matrix Metalloproteinase (MMP) expression. Even under tough climatic conditions, this protects the skin's collagen matrix against UV breakdown and inflammatory cytokine generation.

Manufacturing  and Supply Advantage

Our integrated industrial chain includes citrus farming, R&D, production, quality control, and application development. We support small trial orders and big commercial shipments with 9 modern manufacturing lines and ready stock for standard standards.

We provide flexible FedEx, air, and sea freight operations. Innovation and technical assistance are provided by our Joint Research Center with the Hunan Institute of Agricultural Product Processing and Quality Safety.

Custom specifications, purity levels, packaging design, labeling, and formulation support are available for OEM and ODM. This streamlines regulatory and market compliance.

FAQ

Q: What distinguishes it from Tangeretin?

A: Tangeretin has five methoxy groups, whereas Nobiletin has six. The circadian rhythm control and SIRT1 activation are better with nobiletin.

Q: What is the best storage for no degradation?

A: To last 24 months, store it in a hermetically sealed jar at 2-8°C, away from direct light and moisture.

Q: Can the product be dissolved in water?

A: Being lipophilic, it has minimal aqueous solubility. Lipidome-based carriers or nano-emulsification improve absorption.

Q: Could the product cross the blood-brain barrier?

A: It crosses the BBB due to its high lipophilicity, as shown by Caco-2 permeability experiments. Research shows neuroprotection.

Contact Us

Looking for reliable Nobiletin 478-01-3 supply or custom formulation support? Reach out to our team at sales02@kangbiotech.com to discuss your specific requirements today.