What Is Nobiletin Powder?

Nobiletin powder is a fine off-white powder derived from nobiletin, a polymethoxylated flavone (PMF) found in orange peel. It is 5,6,7,8,3',4'-hexamethoxyflavone with the chemical structure with the CAS number of 478-01-3. And so scientists have studied nobiletin powder for metabolic health, cell defence and circadian rhythm. That’s why manufacturers utilise it in functional meals, dietary supplements and research initiatives. Kang Biotech offer a 98% HPLC version that is safe for food. What is the ingredient? How can we build and try it out? Where does it belong? What should you check before buying?

What Is Nobiletin Powder and Where Does It Come From?

The Chemistry Behind Nobiletin

Molecules of nobiletin are made up of the building blocks C₂₁H₂₂O₈ and weigh about 402.4 g/mol. Because it has six methoxy groups on a flavone backbone, it likes fat more than hydroxylated flavonoids like hesperidin. Methoxylated flavones are better absorbed and don't break down as quickly as their hydroxylated relatives, according to lab work. Because of the same structure, nobiletin doesn't mix well with plain water. Do not get nobiletin and synephrine mixed up. Because nobiletin is a flavone and synephrine is an alkaloid, they are chemically different and are used for different things. Other things that nobiletin powder is not like are broad citrus bioflavonoid blends, which might have hesperidin, naringin, and tangeretin in them. The exact amount of nobiletin should always be checked on the specification sheet.

Citrus Sources and Our Raw Material

Tangerines, mandarins (Citrus reticulata), and sweet oranges (Citrus sinensis) all have nobiletin in their peels. Since content changes based on species, ripeness, and growing region, it's important to keep track of the source. Peels of Citrus sinensis L. are used by Kang Biotech to make nobiletin powder. Our technical team has been extracting citrus fruits for more than 20 years, and as part of an integrated citrus supply chain, we are in charge of over 20,000,000 m² of bitter orange plantations in Lianyuan, Hunan Province. Let us know right away if your internal spec or label plan calls for a certain species, like Citrus reticulata. That way, we can talk about what fits your needs.

Purified Powder Versus Standardized Extract

The nobiletin powder sold in stores is split into two groups. A powder that has been cleaned up, like our 98% HPLC grade, gives a clear active level with little carrier. It has less nobiletin and more other peel compounds than a standardized citrus peel extract. You can find the right HPLC for your needs, as our range goes from 10% to 98%. To get the same amount of nobiletin, a 20% extract needs almost five times as much material as a 98% powder. You can see this in the math. In each quote, look at the type you will get and make sure you understand how the test will be done.

How We Make and Test Nobiletin Powder

From Citrus Peel to Finished Powder

First, peel the citrus fruit to make nobiletin powder. Peel is wet and grinded, and then extract the juice by water or ethanol. To boost the quantity of nobiletin, our team cleans the material with ethanol, removes the solvent, dries it and grinds it to a fine powder. The completed product has 80-100 mesh particles and less than 5% moisture. It is as crucial to regulate the raw materials as the extraction process, since the profile is active based on the source, maturity and traceability. The procedure takes place in a 33,000 square metre structure with 9 manufacturing lines. You may be certain that the provider you chose is qualified, with a specification sheet and batch COA.

Quality Tests and Documents

I believe these are the checks that any individual who buys nobiletin powder should conduct.

• Identity and Assay: The substance is identified by HPLC and purity is reported. Our standard grade purity is 98%. Ask each COA to include the test technique, batch number and test date so you can match the paper record to the drum you get, and have a clear audit chain.
• Contaminant screening: Our CoAs test for heavy metals, microbial load and pesticide residue. Many US companies have their own limits for lead, arsenic, cadmium and mercury so let us know your limits and we will cross reference them against our batch data.
• Physical and paperwork checks: we regulate appearance, moisture 5.0% or less, and particle size 80-100 mesh. Along with each shipment, you will receive a COA, MSDS, allergy statement, GMO-free declaration and BSE/TSE certification for your supplier file.

Your team and your registered dietitian consultant can keep clear records for each lot thanks to these checks.

Certified Production Lines

Our factories are certified by ISO 9001, ISO 22000, HACCP, FAMI-QS, SC (China Food Production License), and Halal, Kosher, and FAMI-QS. Each batch of food is checked in a lab for HACCP and ISO 22000 compliance. Kang Biotech and the Hunan Institute of Agricultural Product Processing and Quality Safety run a joint research center that works on better ways to extract products and make them better overall. Our high-quality paperwork is ready to support filings in places like the US, EU, Japan, and South Korea. If you ask, our sales team can send you the certificates your quality team needs for supplier approval.

Benefits and Uses of Nobiletin Powder

What Research Shows So Far

I think buyers should make it clear that most studies on nobiletin use cells or animals. In a study published in 2016 in Cell Metabolism, researchers discovered that nobiletin works on ROR receptors in the body clock to strengthen clock rhythms in mice. This kept the mice from developing metabolic problems caused by diet. A study published in 2011 in Diabetes found that mice that had diet-induced insulin resistance had less VLDL overproduction and less dyslipidemia. A 2019 paper in Nature Communications found a link between nobiletin and better mitochondrial respiration in mice's muscles. The reason brands look into nobiletin for circadian and metabolic themes is because of these results. They don't show that the same effects happen in people, and there are still not many trials with people.

Writing Claims Within US Rules

The Dietary Supplement Health and Education Act of 1994 says that supplement labels can say what a product does for you, but they can't say that it treats, cures, or stops disease. How you talk about nobiletin powder depends on that rule. A line about supporting a healthy daily rhythm is not the same as a promise to slow down aging, and the second type of language is more likely to cause problems. Labels must have the standard FDA disclaimer and claims must be true and backed up by evidence. Because the FDA doesn't list nobiletin as a separate GRAS substance, you should check with your regulatory counsel about the status of the ingredients and the wording of the claims before the launch.

Where Nobiletin Powder Fits in Products

Since nobiletin dissolves better in fat than in water, oil-based fills and softgels work well together. You can also take it in capsules or tablets, and since it is 98% pure, the amount of fillers is low. Very little of it can be added to bars and baked goods, but drinks need an emulsion or complex to keep it in place. It is used in skin care products at a concentration of 0.1 to 1.0% in creams and serums. The particles are 80 to 100 mesh, which helps keep the product free of grit. Small lots are fine for research labs to start with, and worthy R&D projects can get free 50–100 g samples. Always check the taste, color, and stability of your own base.

Solubility, Dosage, and Safety of Nobiletin Powder

How Soluble Is Nobiletin Powder?

The structure of nobiletin powder makes it hard for water to dissolve. This is still true even if the particles are very small. There are different ways for a powder to mix, suspend, or spread in a drink that are not the same as dissolving it. Many times, oil-based fills, high-shear homogenization with food-grade emulsifiers, or cyclodextrin complexation are used to keep nobiletin spread out evenly in liquids. For each method, the particle size, pH, temperature, and how well it stores need to be tested. We offer a standard grade of 98% HPLC powder at 80–100 mesh, so you can make and test any dispersion system in your own lab. Before you order, we can talk about your base.

Dosage and Dose Math

There isn't a single dose of nobiletin powder that works for all brands. The right amount depends on the format, the audience, the proof, and the rules in your area. People should read the label on the finished product. The formulators only need to do some simple math: the powder weight equals the target amount of nobiletin divided by the assay. For every 100 mg of nobiletin, you need about 102 mg of 98% powder and about 500 mg of a 20% extract. Make room for differences in the assay, processing loss, and stability overage. Then, before you set the serving size, ask your regulatory advisor and dietitian consultant to look it over.

Safety and Precautions

There aren't many safety data on isolated nobiletin in humans yet, so I suggest being careful. Results from labs and animals are not the same as controlled data from people. Some people can't handle concentrated citrus ingredients because they make their stomachs upset. Women who are pregnant or breastfeeding, kids, people who already have health problems, and people who take prescription drugs should talk to a doctor first. Purity is also important for safety, so look at each COA for heavy metals, pesticide residue, and microbiological results. When we ship our food-grade powder, it comes with a statement about allergens, a statement that it is GMO-free, and BSE/TSE certification. The finished formula and its label are still what make the final product safe.

How to Buy Nobiletin Powder

Choosing the Right Specification

First, think about what you want to do. Most supplement brands want a clear active level, so the 98% HPLC grade works well for label planning and keeps carriers low. For foods or blends that need to be cheap, a less pure extract may work. Our range includes 10% to 98% HPLC. Orders for custom purity start at 50 kg, and they take between 15 and 20 days, plus the time it takes to ship. Don't compare prices by kilogram; instead, look at how much nobiletin costs per gram. Don't forget to add the costs of shipping, testing, and importing. For research, it's most important to have purity, identity, and a small pack. Our 1 kg minimum order size is big enough for small trials.

Supply Terms, Samples, and Shipping

You can get samples, and the least you can order is 1 kg. The 98% HPLC grade stock ships in two to three business days. When you order less than 5 kg, FedEx or DHL will bring it to you in 3–7 days. It takes 7–12 days for air freight to get to major hubs with loads between 6 and 100 kg, and 20–35 days for sea freight with loads over 100 kg. A 25 kg fiber drum with a double food-grade PE liner is the standard way to pack it. You can also choose from 1 kg foil bags, 5 kg bags, or 10 kg bags. Store the powder in containers that can't be seen in light, below 25°C, and with less than 60% humidity. When stored correctly, material stays 98% pure for 24 months after it was made.

Mistakes to Avoid

A common mistake is to think of all citrus extracts as nobiletin powder. To get a set nobiletin level, you need more than just the total flavonoid content. You should ask for an active-marker specification. Another will accept a standard COA; make sure to check the lab name, batch number, method, and limits. Just because something is very pure doesn't mean it will work well in a drink or powder blend, so do a test. Some buyers also only look at the price per kilogram, which hides differences in cargo, assay, and freight. Finally, don't use lab research to make claims about health or aging on a label. Make sure that claims are based on facts and follow FDA rules.

Conclusion

With the CAS number 478-01-3, a six-methoxy structure, and low water solubility, nobiletin powder is a polymethoxylated flavone derived from citrus. Buyers should know if the product they are buying is a pure powder or a lower-assay extract because quality depends on where it came from, how it was extracted, the HPLC test, and the test for contaminants. Nobiletin has been linked to circadian and metabolic pathways in cells and animals, but there isn't much evidence in humans yet, so US labels should follow structure-function rules. Assay math tells us how much to use, solubility needs work like oil-based fills or emulsions, and safety depends on the dose, the purity, and the user's health. A good purchase depends on documents that are specific to the batch, clear specifications, claims that are based on facts, and the total cost, not just the price per kilogram.

FAQ

1. Is nobiletin powder the same as citrus peel extract?

No, an extract from citrus peel may only have a small amount of nobiletin among its many other chemicals. Our nobiletin powder is standardized to 98% HPLC, which means that the active level is known and the method is written on the specification sheet.

2. Does nobiletin powder dissolve in water?

Not well. Formulators use oil-based fillers, food-grade emulsifiers, or cyclodextrin complexes to make nobiletin because it likes fat. They then test the stability of the final product. The small size of the particles does not make it dissolve in water.

3. What is the minimum order?

You can get samples, and the least you can order is 1 kg. Research and development projects that qualify can get free samples weighing 50 to 100 grams; just let our team know about your request.

4. How long does the powder last?

When kept in light-proof containers below 25°C and below 60% relative humidity, material stays 98% pure for 24 months after it was made.

5. Which documents come with each shipment?

There is a COA, MSDS, allergen statement, GMO-free declaration, and BSE/TSE certification in every shipment. You can get paperwork for market registration if you ask for it.

Request Nobiletin Powder Samples From Kang Biotech

Are you ready to compare samples? Kang Biotech makes direct nobiletin powder and has 98% HPLC food grade stock. They have a 1 kg minimum order size and offer OEM/ODM service. Send an email to sales02@kangbiotech.com with your application, the purity you want, and the volume you need. Our team will respond with a specification, COA, and quote. You can also look at our range of citrus ingredients at cnkangbiotech.com.

References

1. Cell Metabolism (2016). He et al., study of nobiletin and the circadian clock in mice with metabolic challenge.

2. Diabetes (2011). Mulvihill et al., nobiletin, VLDL overproduction, and dyslipidemia in insulin-resistant mice.

3. Nature Communications (2019). Nohara et al., nobiletin and skeletal muscle mitochondrial respiration in mice.

4. Journal of Functional Foods (2009). Li et al., chemistry and health effects of polymethoxyflavones.

5. Seminars in Cancer Biology (2007). Walle et al., methoxylated flavones and their absorption and metabolic stability.

6. Dietary Supplement Health and Education Act (1994). U.S. Congress, statute governing dietary supplement labeling and structure-function claims.